Departament of Producers Mutagenesis and Strain Improvement
Established in 1965. Head: Olda A. Lapchinskaya, Sc.D.
Faculty:
- O.A.Lapchinskaya, ScD
- E.G.Gladkikh, PhD, Sen. Researcher
- M.O.Makarova, PhD, Sen. Researcher
- G.I.Orlova, PhD, Sen. Researcher
- N.A.Lvova, PhD, Researcher
- V.A.Filicheva, Researcher
- L.A.Kharitonova, Researcher
- V.V.Pogozheva, Researcher
- A.N.Yakovenko, Sen. technololist
- L.I.Nikitina, technician
- A.V.Baganina, technololist
- M.Y.Lapchinskaya, technician
- S.D.Dolgorukova, Sen. technololist
- E.D.Turlyanskaya, technololist
- V.A.Prokpyeva, technololist
Main Research Areas:
- Radiation and chemical mutagenesis in actinomyces culturing
- Primary metabolism and antibiotic production
- Spontaneous and mutation variability of strain producers
- Selection of industrial producers of antibiotics
Major Achievements:
- Development of selection approaches to obtain the super-producers of antibiotics
- Development of the methodology of regulation of the antibiotic production using antimetabolites
- Development of industrial producers of antibacterial (ristomycin, linkomycin, apramycin, tobramycin, heliomycin, eremomycin) and antitumor (daunorubycin, carminomycin, bleomycin, olivomycin, bruneomycin) antibiotics
- Development of veterinary antibiotics (apramycin, heliomycin, ristomycin)
- Discovery of new antibacterial antibiotics, e.g. 3,-deoxykanamycin C and lipoglicopeptide ( INA 5812)
- Active producers of antibacterial (demethylvancomycin) and antifungal (irumamycin) antibiotics
You can see the list of publications of laboratory staff HERE
Research collaboration:
- N.D.Zelinsky Institute of Organic Chemistry Russian Academy of Sciences
Contacts: Phone +7(499)245-01-54; E-mail: lapchinskaya.olda@mail.ru